Thanate Anusaksathien, Kanjana Imsilp, Chaiyan Kasorndorkbua, Angkhana Jaroenworaluck and Aree Thayananuphat

DOI: 10.14456/sjst-psu.2016.55

pp. 421 - 426

Abstract

The objective of the present study was to describe clinical signs and histopathology of the conjunctiva after subconjunctival implantation with poly-lactic acid microfilm (PLA-M) and cyclosporine-containing PLA microfilm (CsPLA-M) in
seven healthy dogs. A randomized, double-blind implantation of a PLA-M and CsPLA-M was performed in each eye. Ocular
clinical signs and Schirmer tear test (STT) levels were determined on days 1, 3, 7, 14, 28, 60 and 90 after implantation. All
implanted eyes had conjunctival hyperemia after implantation which eventually resolved within 90 days. Histopathological
examination of conjunctival biopsy showed mild inflammatory cell infiltration. There was no significant statistical difference
of conjunctival hyperemia scores, STT values or histopathological scores between the two groups. All devices remained
under subconjunctiva at 90 days after implantation. These results suggested that the device was safe and well tolerated for
subconjunctival implantation in dogs.

Keywords

• cyclosporine
• dog
• microfilm
• poly-lactic acid
• subconjunctival implantation