Supinya Tewtrakul, Sanan Subhadhirasakul and Pranee Rattanasuwan

pp. 509 - 514

Abstract

Fifty-two ethanol and water extracts of the plants in Caesalpiniaceae and Papilionaceae families
were screened for their HIV-1 protease (HIV-1 PR) inhibitory activities using high performance liquid chromatography (HPLC) technique. Among the tested extracts, Cassia garrettiana (wood, water extract) showed
the most potent inhibitory activity against HIV-1 PR, followed by Cassia garrettiana (wood, EtOH extract)
and Caesalpinia sappan (wood, EtOH extract) with IC₅₀ of 18, 32 and 75 µg/ml, respectively. The isolation of
active substances against HIV-1 PR of these two plants will be further investigated.

Keywords

• HIV-1 protease
• inhibitory effect
• Caesalpiniaceae
• Papilionaceae