Thanesuan Nuanyai, Benjamat Chailap, Anumart Buakeaw and Songchan Puthong

DOI: 10.14456/sjst-psu.2017.56

pp. 517 - 521

Abstract

A new clerodane diterpene, Caseargrewiin M (1), and one known compound (2) were isolated from fresh ripe fruits of
Casearia grewiifolia. The structures of all isolated compounds were evaluated on the basic 1D (¹H and ¹³C) and 2D NMR
(COSY, HSQC, HMBC and NOESY) spectral data. All compounds were examined cytotoxicity with five human cancer cell
lines, Hep-G₂
 (hepatocarcinoma), SW620 (colon adenocarcinoma), Chago-K1 (undifferentiated lung carcinoma), KATO-III
(gastric carcinoma), and BT474 (breast ductal carcinoma). Isolated compounds showed broad cytotoxicity against five human
cancer cell lines with IC₅₀ values between 0.90–6.30 μg/mL. 

Keywords

• Casearia grewiifolia
• clerodane diterpenoids
• cytotoxicity