The study aimed to prepare and evaluate the physicochemical properties of resveratrol (Res)-loaded lipid-nanocarriers including nanostructured lipid carriers (NLCs) and nanoemulsions (NEs). The effects of composition and process parameters on the physicochemical properties were demonstrated. The optimal formulation was selected to prepare the nanocarrier gels. The possible use of the lipid-nanocarriers in gels and their physical appearances was observed by visual inspection. The results showed that small carriers were prepared by homogenization at 6000 rpm for 5 min. The emulsifier system of Tween®80, Span®80 and diethylene glycol monoethyl ether (DGME) provided good physical stability. The NEs could be prepared for Resloaded NE gels (NEGs) with minimum particle size and optimal zeta potential. Alkyl acrylate crosspolymer (PPM) was the best gelling agent in the formulation. Moreover, the blend of NE and gels (NEGs) was easy to spread on the skin with good occlusive property. Thus, these NEGs have a potential to a nanocarrier for topical delivery of Res.
