Jindaporn Puripattanavong and Supinya Tewtrakul

pp. 37 - 41

Abstract

The leaves from Aglaia andamanica were determined for their anti-allergic and anti-inflammatory effects using RBL2H3 and RAW264.7 cells, respectively. Among the isolated compounds, 24-epi-piscidinol A (5) exhibited the highest antiallergic activity against β-hexosaminidase release with an IC₅₀ value of 19.8 μM, followed by (-)-yangambin (3, IC₅₀ = 33.8

μM), pyramidaglain A (8, IC₅₀ = 37.1 μM), pachypodol (2, IC₅₀ = 38.3 μM) and pyramidaglain B (9, IC₅₀ = 44.8 μM), respectively; whereas other compounds possessed moderate to mild effects (IC₅₀ = 67.5->100 μM). For anti-inflammatory activity,
24-epi-piscidinol A (5) possessed potent activity with an IC₅₀ value of 24.0 μM, followed by pyramidaglain B (9, IC₅₀ = 25.6
μM), pachypodol (2, IC₅₀ = 34.5 μM) and (-)-yangambin (3, IC₅₀ = 37.4 μM), respectively; whereas other compounds
exhibited moderate to mild activities (IC₅₀ = 54.2->100 μM). These active compounds could be developed as anti-allergic and
anti-inflammatory agents in the future.

Keywords

• RBL-2H3 cells
• RAW264.7 cells
• Aglaia andamanica
• Meliaceae