Siti Sakinah Ab Halim, Zuraini Ahmad, Lokman Shamsudin, Muhammad Nazrul Hakim Abdullah and Syarifah Ab Rashid

DOI: 10.14456/sjst-psu.2018.154

pp. 1259 - 1264

Abstract

This study aimed to investigate the effects of Arthrospira (Spirulina) platensis in high cholesterol-fed Sprague-Dawley
rats from a blood biochemistry analysis by evaluating the total cholesterol (TC), high density lipoprotein (HDL), low density
lipoprotein (LDL), triglycerides (TG), and kidney and liver function parameters (total creatinine, blood urea nitrogen, aspartate
aminotransferase, and alanine aminotransferase. The highest levels of TC, LDL, and TG recorded in rats fed the high cholesterol
diet were 5.85±0.16 mmol/L, 2.93±0.65 mmol/L, and 3.32±0.14 mmol/L (P<0.05), respectively. However, these cholesterol
levels were significantly reduced (P<0.05) after Arthrospira supplements (150 mg/kg and 300 mg/kg) for 27 days. There were no
significant changes in HDL levels for all of the treated rats. Throughout the study, the kidney and liver functions of the rats
remained unaffected. In conclusion, both dosages of Arthrospira displayed tremendous potential as an anti-hyperlipidemic agent.

Keywords

• Spirulina sp
• total cholesterol
• blood urea nitrogen
• alanine aminotransferase
• aspartate aminotransferase