The aims of this study were to fabricate cellulose acetate (CA) nanofiber patch containing gac extract using electrospinning process, and to characterize and investigate release and stability of the patch. The patch was successfully prepared using electrospinning process from 17% w/v CA and 3.40% w/v gac extract dissolved in 2:1 v/v acetone/ dimethylacetamide. Diameter of the obtained nanofibers of the patch was 341±63 nm and the gac extract was entrapped well in the nanofibers. Burst release was observed in the release profile of beta-carotene in the extract from the patch and approximately 62 % of beta-carotene was released in an hour. The beta-carotene content in the nanofiber patch remained 50% of the initial amount after 6 months at 40°C and 75%RH, while the physical properties of nanofiber patch were unchanged. This study may enhance the use of gac-loaded CA nanofiber patch and the applications of nanofibers for cosmetic purpose.
