Dujhathai Anekchai and Athip Sakunphueak

DOI: 10.14456/sjst-psu.2021.203

pp. 1556 - 1562

Abstract

Chantaleela (CTL) is a Thai traditional medicine composed of 8 medicinal herbs and borneol and used to treat fever. This study aimed to control the quality of CTL products by establishing a simple but comprehensive method using high performance liquid chromatography (HPLC). HPLC fingerprints of CTL were constructed for assessing qualitative parameters for identification and chemical profiling. This method is highly precise and accurate in quantifying the constituents of CTL identifying markers including eurycomanone, loureirin A, imperatorin and atractylodin. The quality of commercial CTL products in Thailand was assessed using this developed method. The chromatographic pattern was noticeably different from the established reference fingerprints. The substitution of Artemisia vulgaris for Artemisia annua was found in every commercial product. Moreover, the low content of marker compounds reflected poor quality of the commercial products.

Keywords

• Chantaleela
• HPLC fingerprint
• quality control
• traditional medicine
• combinative herbal preparation