Theerapich Paopeng, Kornkanok Ingkaninan, Jarupa Viyoch, Wudtichai Wisuitiprot and Neti Waranuch

DOI: 10.14456/sjst-psu.2019.160

pp. 1275 - 1281

Abstract

Asparagus racemosus Willd., known as Shatavari (Rak-Sam-Sib in the Thai language), has been used in traditional
medicine and as a food supplement for females with hormone related health conditions due to its estrogenic effects. In cosmetic
use, a clinical study in adult volunteers showed an efficacy in delayed wrinkle formation with topical application. In this study,
we focused on the effect of A. racemosus root extract on the expression of type I procollagen and matrix metalloproteinase-1
(MMP-1) in ultraviolet B (UVB) treated human dermal fibroblasts. The saponin enriched extract of A. racemosus root was shown
to promote type I procollagen synthesis in non-UVB-exposed cells and prevent a decrease in type I procollagen secretion in UVB
exposed cells. Moreover, the enhanced MMP-1 expression upon UVB irradiation was suppressed by A. racemosus root extract.
These results suggested A. racemosus root extract could be a potential agent as an anti-photoaging ingredient in cosmeceuticals.

Keywords

• Asparagus racemosus
• photoaging
• procollagen
• MMP-1
• UVB