Kingkan Bunluepuech and Supinya Tewtrakul

pp. 289 - 292

Abstract

For the purpose of discovering anti-HIV-1 agents from natural sources, the aqueous and EtOH extracts of eight Thai plants including Clerodendron indicum (whole plant), Tiliacora triandra (stem), Capparis micracantha (wood), Harrissonia perforata (wood), Ficus glomerata (wood), Diospyros decandra (wood), Dracaena loureiri (heartwood), and Tinospora
crispa (stem) were screened for their inhibitory activities against HIV-1 integrase (IN) using the multiplate integration assay (MIA). Of the EtOH extracts, Ficus glomerata (wood) was the most potent with an IC₅₀ value of 7.8 μg/ml; whereas the water extract of Harrisonia perforata (wood) was the most potent aqueous extract with an IC₅₀ value of 2.3 μg/ml. The
isolation of active principles against HIV-1 IN from Ficus glomerata is now actively pursued.

Keywords

• anti-HIV-1 integrase activity
• Thai plants
• Ficus glomerata
• Harrisonia perforata