Original Article |
2012, Vol.34, No.3, pp. 293-301
Overview of RNA interference therapeutics
Nattanan T-Thienprasert Panjaworayan
pp. 293 - 301
Abstract
Since the term RNA interference (RNAi) was coined in 1998, much knowledge about RNAi has accumulated. Presently, RNAi is known as a power tool for studying gene function as well as a potential therapeutic molecular technique for a wide range of disorders. This review discusses potential problem areas such as off-target effects, in vivo delivery and RNAi saturation, and also indicates solutions including the current stage of RNAi therapeutics.