Sutita Nudmamud-Thanoi, Nareelak Tangsrisakda, and Samur Thanoi

DOI: 10.14456/sjst-psu.2016.37

pp. 275 - 279

Abstract

Methamphetamine (METH) is toxic not only to the central nervous system but also to the reproductive system. This
study aimed to investigate the effect of METH administration on androgen receptor (AR) expression in the seminiferous
tubules (stages VII-VIII) and Leydig cells. 24 Sprague-Dawley rats were equally divided into 4 groups; control, acute doseMETH binge (AB-METH), escalating dose-METH (ED-METH) and escalating dose-METH binge (ED-METH binge) groups.
The expressions of AR were examined using immunohistochemical staining. AR expressions in round and elongated
spermatids showed significant decreases in ED-METH binge and AB-METH groups. In Leydig’s cells, AR expressions were
significantly decreased in both ED-METH and ED-METH binge groups. These results could reflect the effect of METH on
the expressions of AR in both round and elongated spermatids of stages VII-VIII seminiferous tubule and Leydig’s cells.
Decreases of AR expressions in those cells of METH-treated animals may interrupt spermatogenesis at these stages.