Panit Suavansri and Nataphan Kitisin

DOI: 10.14456/sjst-psu.2018.138

pp. 1115 - 1124

Abstract

A mathematical model of the death rate of malaria parasite due to the antimalarial drugs is established in this paper to
predict the treatment duration and the drug dosage. This model is based on probabilities, pharmacokinetics and pharmacodynamics (PK/PD), biology, medical sciences, theoretical physics and chemistry. The death rate of malaria parasite is derived
from the flow rates of drug molecules to the malaria parasite by using the theory of blood convection and probabilities. Using the
malaria model, numerical results are generated. In conclusion, the numerical estimate of treatment duration from our model
ranges from 1 to 10 days, conforming to actual clinical data.