Hestiary Ratih, Jessie Sofia Pamudji, Fikri Alatas, and Sundani Nurono Soewandhi

DOI: 10.14456/sjst-psu.2020.25

pp. 188 - 195

Abstract

Telmisartan (TMS) is used for the prevention and treatment of hypertension. However, it has poor mechanical
properties. The purpose of this research was to improve the mechanical properties of TMS through the formation of co-crystal
TMS with oxalic acid (OXA) and to compare the mechanical properties of TMS-OXA 1:1 co-crystal obtained from the different
co-crystallization techniques. Co-crystals were prepared by the slow evaporation (SE) and ultrasound assisted co-crystallization
from solution (USSC) methods. The tabletability profiles were plotted between compaction forces in the range of 4.98‒29.89 kN
vs. tensile strength. The tablet tensile strength of TMS in compaction force >14.98 kN had severe capping or lamination. In
contrast, the tablet tensile strengths of the TMS-OXA SE and USSC co-crystals were higher and could be easily formed into
tablets in all of the compaction forces. It can be concluded that the TMS-OXA co-crystals prepared by the SE and USSC methods
have improved mechanical properties of the telmisartan tablet.