Trisha Mary P. A., Sharmila Srimathi D., Arya R. Krishna, Jayaprabha. C, Swathy Krishna J., and Suganthi Ramasamy

DOI: 10.14456/sjst-psu.2021.137

pp. 1041 - 1048

Abstract

Melanins are ubiquitous pigments which are naturally produced and distributed throughout the biological kingdom.
Pseudomonas mosselii strain STSGRDS1 producing melanin was used in the study. STSGRDS1 melanin reported to have metal
chelating potential of increasing effect with increase in the concentration of melanin. The anti-proliferative activity of the
purified melanin by MTT assay had IC₅₀ value 87.15µg/ml towards A431skin cancer cell line for standard 5-flurouracil and also
showed substantial apoptotic activity. The minimal inhibitory concentration (MIC) against bacteria and fungi were also
evaluated. Hence, the purified melanin having anti-proliferative properties can be exploited in therapeutic applications.