Hospital readmissions for heart failure are a major clinical problem and associated financial burden. However, readmission rate in heart failure remains high. This study aimed to test a model explaining the factors influencing readmission in people with heart failure. In total, 204 patients with heart failure were recruited at four regional hospitals in Thailand. All research instruments used showed acceptable validity and reliability. The data were analyzed using version 8.72 of Linear Structural Relationship. The results showed that the hypothetical model matched the empirical data. The severity of symptoms was the factor that had the most impact on readmission and had a direct positive effect on readmission, followed by quality of life and depression. An intervention study to prevent readmission in heart failure patients should be developed and tested as well. It should incorporate the promotion of social support and quality of life to reduce readmission in heart failure patients.