Jintana Masoongnoen, Sompong Sansenya, Kongaphisith Tongpoolsomjit, Jarupa Viyoch, and Kanokorn Wechakorn

DOI: 10.14456/sjst-psu.2022.99

pp. 735 - 743

Abstract

The crude extracts from medicinal plants are increasingly important for bioactive activities. Several parts of Morinda
citrifolia have been utilized in traditional medicine, such as diabetes, anticancer, and hypertension. Therefore, the purpose of this
research was to investigate the biological activities, e.g., antioxidant, antidiabetic, and tyrosinase inhibitory activity of the crude
extracts of Morinda citrifolia unripe fruits. The highest percent extraction was found in methanol. The purified methanoic
fraction displayed the highest total phenolic content and was a potent tyrosinase inhibitor. The fraction of ethyl acetate exhibited
the highest flavonoid content and DPPH free radical scavenging capacity. Furthermore, the ethyl acetate and methanol fractions
were investigated as potent α-glucosidase and α-amylase inhibitors. Additionally, the cytotoxicity test of the bioactive fractions
was explored in human keratinocyte cell lines.