Duo Li, Xiaomei Yu, Sirithon Siriamornpun, Xiaoqun Zhou, Jiajin Zhu, Yonghua Zhang, Ting Yao, and Andrew J. Sinclair

pp. 133 - 137

Abstract

Uric acid is the final metabolite of purine. Increased serum uric acid level is associated with incidence of gout and cardiovascular diseases. The aim of this study was to investigate the relationship between serum uric acid and parameters of biochemistry and haematology in Hangzhou populations, China. In this crosssectional study, 186 male (56±14 y) and 85 female (55±11 y) free-living subjects were recruited from Hangzhou,
China. The physiological parameters were measured. Each subject gave fasting blood, urine and faeces samples, from which serum uric acid and other parameters of biochemistry and haematology were measured with standard methods. Serum uric concentration was significantly higher in males than in females, 329±69
µmol/L for male and 237±53 µmol/L for female (P<0.0001). Compared with female subjects, male had significantly higher BMI (P = 0.0215), serum TAG (P = 0.0012) and creatinine (P<0.0001), significantly lower TC (P = 0.0013) and HDL-C (P<0.0001). Bivariate analysis results showed that serum uric acid was significantly
positively correlated with age (r = 0.171, P = 0.0076), BMI (r = 0.343, P<0.0001), systolic blood pressure (r =0.234, P = 0.0002), diastolic blood pressure (r = 0.204, P = 0.0014), blood urea nitrogen (r = 0.251, P<0.0001), serum concentrations of total cholesterol (r = 0.192, P = 0.0026) and triacylglycerol (r = 0.306, P<0.0001), and
significantly negatively correlated with HDL-cholesterol (r = -0.381, P<0.0001). In the bivariate analysis for separate gender, serum uric acid concentration was significantly positively correlated with TC (r = 0.255,P = 0.001), LDL-C (r = 0.329, P<0.0001) and HDL-C (r = -0.185, P = 0.0181) for males, but not for females.Serum uric acid concentration was significantly positively correlated with age for females (r = 0.289, P =
0.0081), but not for males. The results from the present study indicated that increased serum uric acid concentration was associated with a cluster of the cardiovascular risk factors in Hangzhou populations.