Nattanan T-Thienprasert Panjaworayan

pp. 293 - 301

Abstract

Since the term RNA interference (RNAi) was coined in 1998, much knowledge about RNAi has accumulated. Presently,
RNAi is known as a power tool for studying gene function as well as a potential therapeutic molecular technique for a wide
range of disorders. This review discusses potential problem areas such as off-target effects, in vivo delivery and RNAi
saturation, and also indicates solutions including the current stage of RNAi therapeutics.

Keywords

• RNA inference
• siRNA
• off-target effects
• delivery
• RNAi therapeutics